ExtremeMhz plugged a USB drive into a Vista machine, to find out what speed increase you get when using ReadyBoost.  As it turns out, the only time you will feel it is on startup and when loading programs.  As only managed to shave a few seconds off of the longest tasks, you may not even notice it then.  It is very possible that a larger drive that they used would give you more benefit, so stick with larger than 512MB.
‘Windows Vista has certainly gotten its fair share of criticism since its official release, and with good reason. After playing with Vista for so long now, I remain quite frustrated, even after fiddling around with the final retail release. There’s just too many issues many will have to face and somewhat force them to take the time to research in order to work them out and keep them sane! I’ve found that unless your an avid computer user, you won’t be able to figure out how to remedy many of the issues you will face with both hardware and software. However, that’s not the purpose of this article. Despite its flaws, Vista does incorporate a number of very useful features that many may not even be aware of. One of these features happens to be ReadyBoost, which will be covered in detail in this short article, including my personal thoughts on what an impact it may have with flash drive manufacturers.’

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