Has this ever happened to you while playing a shooter? You need to get to a position so you mash the alt key to sprint and… aw crap I hit the Windows key… well, now I am dead. Have you ever considered purchasing software or a gaming keyboard which allows you disable that button?
Have you ever considered purchasing a mouse which also has that button to give both hands something to fear?
Definitely not a member of their Sidewinder product line.
Okay, so I should be fair: the Microsoft Sculpt Comfort mouse is not designed for gaming and Windows 8-like user experiences revolve heavily around the start button. The mouse button is also more useful than a redundant Windows key; the blue pad also has swipe functionality for extra functions. According to how it is described on its product page, slide gestures are bound to respond to the computer as mouse buttons 4 and 5.
So you can probably bind them to game functions, if you feel daring.
But, in the end, I still need to congratulate Microsoft for trying to innovate computer hardware. This is more than just trying to graft touch functionality to a mouse surface, as both Apple and Microsoft have tried in the past, and tries to make the classical mouse experience better. I doubt it is for most of our audience, but not everything needs to be.