Counting the different mouse wheel directions and the Easy-Shift button alternate pressing you can program up to 32 different buttons on the Roccat Tyon mouse.  As even the mouse wheel can be programmed to function completely differently between scrolling directions, this should count as long as your game supports it.  Not only do you get a ridiculous amount of customization, the nub you see on top of the mouse can function just like the throttle slider on your joystick, an interesting feature considering the number of space sims launching in the near future.  Hardware Asylum really like the mouse though they did dock points for not being usable by sinister types, check out the full review and the software suite right here.

"The Tyon has innovative buttons just where you expect them without becoming overwhelming. Maybe the best part is you don’t even notice them when you don’t want to use them."

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